Smoking and Wrinkles

The fact that people who smoke develop wrinkles at an earlier age than their non-smoking counterparts seems to be due to an imbalance of extracellular matrix degrading enzymes and their respective inhibiting factors, according to an article in the Lancet (2001;357:935-6).

Researchers investigating the role of ultraviolet light on the expression of matrix metalloproteinase (MMP) enzymes in buttock skin of healthy volunteers incidentally found that this enzyme was already being expressed before ultraviolet exposure in some individuals, but not in others. Volunteers were retrospectively asked about their smoking status, and results indicated that smokers were more likely to express these enzymes than were non- smokers. There was no change in the expression of the known inhibiting factors between smokers and non-smokers.

The skin is a dynamic organ and depends on the deposition and remodelling of extracellular matrix proteins and terminal differentiation of basal cells into keratinocytes. Collagen accounts for more than 70% of the dry weight of skin, is the predominant protein of the extracellular matrix, and is degraded by these proteolytic MMP enzymes. MMPs are held in check by specific inhibitors, a relationship much like the proteinase-antiproteinase balance within the lung, which is deranged in individuals with a-1-antitrypsin deficiency, which manifests clinically as emphysema.

Increased expression of MMPs but not their inhibitors has been proposed to cause local degradation of collagens within the skin, resulting in loss of tone and eventually in wrinkles. Previous studies have shown the imbalance between MMPs and their inhibitors in response to sunlight, but this is the first report to show that smoking alters their equilibrium in vivo. Work published last year in the Archives of Dermatological Research (2000;292:18894) showed that human fibroblasts in vitro expressed MMPs in a dose dependent manner in response to increasing doses of water soluble extract from tobacco smoke.

While skin wrinkling is not an independent risk factor for increased morbidity or mortality on its own, this research may provide further data on how smoking mediates its other deleterious effects on individuals, and these findings could also be used in the fight against smoking.

Disclaimer: this website is for informational purposes only, and is not intended to be a substitute for a professional medical diagnosis, opinion or suggested course of treatment. Please see your health care professional for a professional medical opinion, and refer to our Disclaimer regarding your use of this website.

Close Window  X


ChestSavers / Chest Savers are Registered Trademarks
ChestSavers Bra/Brassiere - Patent Pending
ChestSavers Lingerie - Patents Pending
Simply Smooth - Patent Pending
Second Skin - Patent Pending
ChestSavers II - Patent Pending
ChestSavers II System - Patent Pending
NeckSavers - Patent Pending

© Copyright 2011.  All rights reserved.

Disclaimer l Return Policy l Affiliates l Careers l Webmaster l Site Map l Links


Article on Chest Wrinkles/ Age & Wrinkles/ Chest Wrinkles/ Neck Wrinkles/ Face Wrinkles/ Skin Health/ Facial Skin Health/ Sagging Face Skin/ Sagging Neck Skin/ Diet & Wrinkles/ Exercise & Wrinkles/ Smoking & Wrinkles/ Stress & Wrinkles/ Self Esteem & Wrinkles/ Happiness & Wrinkles/ Depression & Wrinkles/ Anger & Wrinkles/ Beauty & Wrinkles/ Removing Chest Wrinkles/ Removing Face Wrinkles/ Remove Neck Wrinkles/ Plastic Surgery/ Cosmetic Procedures / Cosmetic Surgeries/ Eye Lifts/ Chin Implants/ Tummy Tuck (Abdominoplasty)/ Loose Skin/ Nose Cosmetic Surgery (Rhinoplasty)/ Botox/ Laser Cosmetic Surgery/ Chemical Peel/ Dermabrasion/ Collagen Injections/ Lip Augmentation Enhancement/ Laser Hair Removal/ Aestheticians/ Browlift/ Facelift/ Breast Augmentation/ Liposuction/ Cosmetic Breast Surgery/ Cheek Augmentation/ Cheek Fat Removal/ Ear Surgery/ Endoscopic Facial Surgery/ Eyelid Ptosis Surgery/ Eyelid Surgery/ Eyelid Tightening/ Facial Implants/ Fat Injections/ Lip Lift/ Lip Reduction/ Liposuction Cheek, Jowl, Chin & Neck/ Midface Lift (Cheek Lift)/ Neck Lift/ Neck Muscle Repair/ Revision Rhinoplasty/ Soof Lift/ Cellulite/ Stretch Marks/ Skin Bleaching/ Tanning/

Anti-Aging and Medications/ Anti-Aging and Sleep/ Anti-Aging and Your Teeth/ Anti-Aging and Your Hair/ Anti-Aging and Your Eyes/ Anti-Aging and Your Skin/ Anti-Aging and Chest Wrinkles/ Anti-Aging and Neck Wrinkles/ Anti-Aging and Your Body/ Anti-Aging and Your Nails/ Anti-Aging and Your Hands/ Anti-Aging and Your Smile/ Anti-Aging and Your Lips/ Anti-Aging and Your Youthful Glow/ Anti-Aging Strategies/

Eyebrow Shaping/ Makeup/ Anti-Aging Cosmetics/ Anti-Aging Beauty Products

Google Search/ /Yahoo Search/ /MSN Search

What our Customers say...

My chest wrinkles were turning into deep chest creases. Thank you Chest Savers for getting rid of my wrinkles, Deb, Omaha.

You helped me rid of both my chest wrinkles and neck wrinkles. Thank you. Dawn, Laguna Beach

No more chest wrinkles or neck wrinkles. Laura, New York City

Chest wrinkles and neck wrinkles are no longer a problem for me. Thank you. Deborah, Miami

Great products for eliminating chest and neck wrinkles. Anita, Bellingham

I feel years younger and youthful due to getting rid of the chest wrinkles. Thanks. Bea, Redding

Chest wrinkles and neck wrinkles had been a problem for me for many years. Thank you. Louise, Bakersfield

The wrinkles on my chest are gone. Thank you. Monica, Redlands

I use your product because I don't want to get chest wrinkles. Lisa, Chicago